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Category:
chemistry (990) biology (196)
Status:
Approved (201) Withdrawn (10) NDA Filing (14) BLA Filing (5) Phase Ⅲ (144) Phase Ⅱ (442) Phase Ⅰ (368) IND Filing (2)
Clinical Stage:
Pending (182) Active (272) Discontinued (520)
Bio-Type:
Gene therapy (6) Immunocytokine (2) Cell therapy (1) CAR T cell therapy (5) TCR therapy (5) Oncolytic virus (1) Vaccine (58) Blood extraction (1) Allergen extract (2) Recombinant enzyme (2) Recombinant coagulation factor (1) Recombinant cytokines (10) Recombinant hormone (8) Recombinant glycoprotein (1) Bispecific antibody (5) Other recombinant protein (1) Whole antibody (50) ADC (5) Fusion protein (3)
Indication:
Meningitis (1) Non-alcoholic steatohepatitis (1) Acne (1) Acute bacterial skin and skin structure infections (ABSSSI) (2) Acute coronary syndrome (ACS) (7) Acute lymphoblastic leukaemia (ALL) (4) Acute myeloid Leukemia (AML) (18) Advanced or metastatic breast cancer (1) Advanced renal cell carcinoma (RCC) (1) Alcohol dependence (2) Allergic rhinitis (AR) (7) Alzheimer's disease (AD) (33) Amyotrophic lateral sclerosis (ALS) (3) Anaesthetic (3) Anemia (4) Angina pectoris (6) Anxiety (25) Arrhythmia (11) Arthritis (2) Aspergillosis (1) Asthma (43) Atherosclerosis (8) Atopic dermatitis (4) Atrial fibrillation (5) Atrial flutter (1) Attention deficit hyperactivity disorder (ADHD) (2) Basal cell carcinoma (BCC) (2) BCG-refractory carcinoma in situ of the urinary bladder (1) Benign prostatic hypertrophy (13) Bipolar I disorder (1) Bladder cancer (5) Mercury poisoning (1) lead poisoning (1) Breast cancer (30) Bronchial asthma (2) Cancer related cachexia (1) Cancer related pain (1) Candidiasis (2) Herpes zoster (1) Cerebral vasospasm (1) Conjunctivitis (1) Chemotherapy-induced nausea and vomiting (6) Oedema (2) Chronic idiopathic urticaria (CIU) (2) Chronic immune thrombocytopenia (1) Chronic lymphocytic leukemia (CLL) (7) Mucocutaneous lymph node syndrome (Kawasaki syndrome) (1) Agammaglobulinaemia (1) Chronic myeloid leukemia (CML ) (2) Chronic obstructive pulmonary disease (COPD) (12) Chronic pain (1) ischaemic heart disorder (7) Clostridium difficile infection (1) Clostridium difficile-associated diarrhea (CDAD) (2) Cutaneous larva migrans (1) Dracunculiasis (1) Cognitive disorders (10) Colorectal neoplasms (1) Community-acquired pneumonia (CAP) (3) Complicated intra-abdominal infection (1) Toxocariasis (1) Complicated urinary tract infection (1) Congestive heart failure (1) Constipation (2) Menopausal symptoms (2) Coronary artery disease (CAD) (2) Crohn's disease (4) Cutaneous fungal infections (2) Avian influenza (1) Cutaneous T cell lymphoma (CTCL) (1) Respiratory-tract disorders (1) Cystic fibrosis (CF) (2) Peripheral vascular disorders (2) Deep vein thrombosis (DVT) (3) Dementia (1) Depression (13) Diabetic macular edema (3) Diabetic nephropathy (5) Herpes simplex virus (2) Diarrhea (1) Differentiated thyroid cancer (1) Infections of the eye (1) Duchenne muscular dystrophy (DMD) (1) Dyslipidemia (3) Dysmenorrhea (2) Dyspepsia (2) Dysuria (1) Eczema (2) Endometrial cancer (2) Rheumatic disorders (6) Endometriosis (1) Transplant rejection (1) Epilepsy/Seizures (9) Erectile dysfunction (ED) (6) Anal cancer (3) Penile cancer (1) Vulvovaginal cancer (3) Urogenital cancer (2) Essential hypertension-重复 (3) Essential thrombocythaemia (ET) (1) Exercise-induced bronchoconstriction (EIB) (1) Familial chylomicronemia syndrome (FCS) (1) Female sexual dysfunction (1) Fibromyalgia (FM) (1) Follicular lymphoma (2) Fragile X syndrome (1) Gastric cancer (6) Gastric ulcer (2) Gastroesophageal reflux disease (GERD) (2) Gastrointestinal stromal tumors (GISTs) (2) Generalised anxiety disorder (GAD) (3) Digital ulcers (1) Pancreatitis (1) Glaucoma (4) Glioblastoma multiforme (5) Gonorrhea (1) Gram-positive and Gram-negative bacterial infections (1) Wet age-related macular degeneration (1) Growth hormone deficit (1) Cytomegalovirus infections (7) HBV infection (12) HCV infection (42) Behavioural disorders (1) Heart failure (18) Hepatocellular carcinoma (HCC) (9) HIV infection (36) Hormone refractory prostate cancer (1) Huntington's disease (2) Hypercalcemia (1) Timothy grass pollen-induced allergic rhinitis (1) Hypercholesterolemia (8) Hyperlipidemia (12) Hypertension (38) Hypertriglyceridemia (1) Hyperuricemia (2) Hypogonadotropic hypogonadism (2) Hyponatremia (1) Idiopathic pulmonary fibrosis (IPF) (2) Idiopathic thrombocytopenic purpura (ITP) (1) Inflammatory bowel disease (5) Influenza virus infection (4) Insomnia (11) Invasive aspergillosis (2) Hepatitis A viral infection (1) Chronic inflammatory demyelinating polyradiculoneuropathy (1) Irritable bowel syndrome (IBS) (4) Rabies (1) Juvenile rheumatoid arthritis (JRA) (2) Keratinocytes type scabies (1) Stevens-Johnson syndrome (1) Toxic epidermal necrolysis (1) Leiomyoma (2) Lesch-Nyhan Disease (1) Leukemia (5) Lung cancer (4) Lymphoma (13) Macular degeneration (1) Major depressive disorder (MDD) (27) Malignancies (8) Graves ophthalmopathy (1) Mania (3) Mantle cell lymphoma (MCL) (2) Medulloblastoma (1) Melanoma (21) Metastatic breast cancer (3) Metastatic prostate carcinoma (1) Metastatic colorectal cancer (CRC) (3) Metastatic gastric carcinoma (1) Metastatic melanoma (1) Migraine (8) Mood disorder (1) Multiple myeloma (MM) (10) Multiple sclerosis (MS) (9) Muscle relaxant (1) Myelodysplastic syndrome (MDS) (4) Myelofibrosis (1) Myeloid leukemia (1) Myocardial infarction (MI) (13) Nail scabies (1) Nausea and vomiting (5) Systemic amyloidosis (1) Neuropathic pain (12) Non small cell lung cancer (NSCLC) (29) Non-alcoholic fatty liver disease (NAFLD) (1) Non-Hodgkin B-cell lymphomas (2) Non-Hodgkin’s lymphoma (NHL) (6) Non-ST elevation acute coronary syndrome (NSTE-ACS) (2) Obesity (12) Ocular hypertension (4) Open-angle glaucoma (3) Osteoarthritis (OA) (11) Gynaecological cancer (1) Osteoporosis (4) Osteosarcoma (1) Nephritis (1) Ovarian cancer (21) Overactive bladder (OAB) (11) Ovulation induction (1) Paget's disease (1) Pancreatic cancer (25) Parkinson's disease (PD) (18) Choriocarcinoma (1) Pelvic inflammatory disease (1) Peptic ulcer (7) Percutaneous coronary intervention (PCI) (2) Perennial allergic rhinitis (3) Peripheral arterial disease (PAD) (6) Pneumonia (6) Postherpetic neuralgia (PHN) (3) Postmenopausal osteoporosis (4) Postoperative nausea and vomiting (1) Postoperative pain (4) Viral infections (3) Post-polycythemia vera (2) Thrombosis (1) Primary hypercholesterolemia (1) Kidney disorders (1) Diphtheria (5) Haemophilus infection (4) Pertussis (5) Prostate cancer (19) Poliomyelitis (2) Tetanus (5) Psoriasis (8) Psoriatic arthritis (5) Pulmonary arterial hypertension (3) Pulmonary embolism (2) Rejection of organ transplantation (2) Renal cell carcinoma (3) Respiratory tract infection (1) Rheumatoid arthritis (RA) (34) Schizophrenia (32) Seasonal allergic rhinitis (4) Zika virus infection (1) Sedation (5) Sensitive anaerobic bacteria infections (2) Sjoegren's syndrome (1) Sleep disorder (6) Sleep initiation and maintenance disorders (1) Small cell lung cancer (SCLC) (5) Smoking cessation (2) Male infertility (1) Soft tissue sarcoma (3) Solid tumours (133) Systemic lupus erythematosus (3) Peanut hypersensitivity (1) Thrombotic cardiovascular events (TCE) (2) Metabolic disorders (1) Germ cell and embryonal neoplasms (1) Topical bacterial infection (1) Heart arrest (1) Tourette's syndrome (1) Triple negative breast cancer (2) Tuberculosis (2) Usher syndrome (1) Type 2 diabetes (44) Ulcerative colitis (8) Urinary incontinence (9) Urinary tract infections (3) Urticaria (2) Uveitis (2) Rhabdomyosarcoma (2) Venous thromboembolism (VTE) (4) Reperfusion injury (1) Head and neck cancer (10) Genital warts (2) Influenza A virus infections (2) Fabry disease (1) Hodgkin lymphoma (2) Cardiac ischemic complications (1) Colorectal cancer (26) Cryopyrin-Associated Periodic Syndromes (CAPS) (1) Prophylaxis of organ rejection (1) Vulvar intraepithelial neoplasia (1) Rejection of renal transplantation (1) Rejection of liver transplantation (2) Rejection of lung transplantation (1) Myocardial reperfusion injury (1) Rejection of pancreatic transplantation (1) Primary peritoneal cancer (1) Fallopian tube cancer (2) Picornavirus infections (1) Epithelial ovarian cancer (2) Ventricular arrhythmias (2) Ankylosing Spondylitis (AS) (6) Acute pain (AP) (2) Pulmonary arterial hypertension secondary to scleroderma (1) Nosocomial infections (1) Tinea corporis (1) Tinea cruris (1) Tinea pedis (1) Fungal infection (5) Nosocomial Pneumonia (NP) (1) Meningococcal infection (1) Gestational trophoblastic disease (1) Nonseminomatous testicular cancer (1) Wilms Tumor (1) Chronic kidney disease (1) Colon cancer (3) Complicated skin and skin structure infections (cSSSI) (1) Cirrhosis (1) Dermatitis (3) Hepatitis (1) Skin pruritus (2) Susceptible bacterial infections (1) Chronic heart failure (1) Acute angina (1) Familial hypercholesterolemia (1) Neuroblastoma (4) Muckle-Wells Syndrome (MWS) (1) Age-related macular degeneration (AMD) (6) Oropharyngeal candidiasis (OPC) (1) Refractory fungal infections (1) Thrush (1) Invasive fungal infection (1) Unresectable hepatocellular carcinoma (1) Trichophyton rubrum infection (1) Epidermophyton floccosum infection (1) Ringworm (1) Tinea versicolor (1) Bacterial conjunctivitis (1) Accelerate gastrointestinal recovery following surgeries (1) Pain (18) Stroke (11) Reversal of Neuromuscular Blockade (1) Unstable angina (7) Non-ST segment elevation myocardial infarction (NSTEMI) (1) ST-segment elevation myocardial infarction (STEMI) (2) Anaplastic astrocytoma (1) Malignant glioma (2) Prophylaxis of surgical site infection following elective colorectal surgery (1) Intra-abdominal infections (1) Acute gynaecological infections (1) Diabetic foot infections of the skin and soft tissue (1) Prevention of postmenopausal osteoporosis (1) Bone pain (1) Hepatic impairment (1) Symptomatic spontaneous superficial-vein thrombosis of the lower limbs (1) Acute pulmonary thromboembolism (1) Autistic disorder (1) Acute gouty arthritis (GA) (1) Primary hyperlipidemia (1) Mixed hyperlipidemia (2) Homozygous familial hypercholesterolemia (1) Homozygous sitosterolemia (1) Anesthesia (5) Biliary cancer (2) Prostatitis (1) Systemic inflammatory response syndrome (SIRS) (1) Recurrence suppression after ischemic cerebrovascular disorder (1) Stable angina (1) Old myocardial infarction (1) Recent myocardial infarction (1) Cervical carcinoma (9) Lower respiratory tract disease caused by RSV (1) Macular edema (1) Sarcoma (7) Meningioma (1) B-cell lymphoma (4) Diabetes (9) Behcet's disease (1) Pediatric Crohn’s disease (3) Pediatric ulcerative colitis (1) Familial cold autoinflammatory syndrome (1) Malaria (4) Recurrent glioma (1) Sickle cell disease (1) Type 1 diabetes (4) Hairy cell leukemia (2) Condylomata acuminata (2) Kaposi's sarcoma (2) Renal carcinoma (6) Acute ischemic stroke (AIS) (1) Acute myocardial infarction (AMI) (1) Post-traumatic stress disorder (1) Contraception (5) Hypertrophic cardiomyopathy (1) Hematological cancer (2) Plasma uric acid management (1) Disseminated intravascular coagulation (DIC) (1) Spinal cord injury (1) Hereditary angioedema (HAE) (3) Spinal muscular atrophy (3) Hyperphosphatemia (1) Infertility (6) Autoimmune diseases (4) Down's syndrome (1) Obsessive compulsive disorder (1) Growth failure (1) Acute heart failure (2) Esophageal adenocarcinoma (1) Septic shock (1) Gram-positive bacterial infection (2) Hypoglycemia (1) Preterm labor (2) Peritoneum cancer (3) B-cell malignancies (1) Renal insufficiency (1) Alcoholism (1) Pruritus (1) Chemotherapy-radiotherapy induced mucositis (1) Myelodysplasia (2) Anorexia nervosa (1) Progressive supranuclear palsy (1) Trypanosomiasis (1) Leishmaniasis (1) HDV infection (1) Fibrodysplasia ossificans progressiva (FOP) (2) Staphylococcal infection (2) Brain injury (4) Premenstrual syndrome(PMS) (1) Lymphoblastic leukaemia (1) Thymic tumor (1) RSV infection (1) Glioblastoma (8) Glioma (2) Myasthenia (1) Graft versus host disease (1) Ewing's Sarcoma (3) Neuroendocrine tumors (NET) (1) Clostridial infection (1) Advanced melanoma (1) Plaque psoriasis (4) Allergic asthma (3) Gout (1) Thrombosis (19) Breast pain (1) Enterovirus infection (1) Alopecia (1) Systemic sclerosis (1) Coronary heart disease (2) Respiratory syncytial virus infection (1) Mesothelioma (6) Diffuse large B cell lymphoma (1) Androgen deficiency (1) Dengue fever (2) Vasomotor symptoms (2) Brain cancer (3) Lipodystrophy (2) Bacterial infection (10) Muscle spasticity (3) Cocaine abuse (2) Pervasive child developmental disorder (1) Aortic valve stenosis (1) Celiac disease (1) Poliovirus infection (2) Cough (4) Post-surgical adhesions (1) Stargardt’s disease (1) Diabetic neuropathy (2) Liver cancer (1) Thelassemia (1) Polycystic kidney disease (PKD) (1) Sarcopenia (2) Obstructive Sleep Apnea/Hypopnea Syndrome (OSA/HS) (1) Renal failure (1) Psychiatric disorders (3) Coronary restenosis (3) Thromboembolism (2) Infectious disease (2) Neurological disease (3) hematological malignancies (1) Central nervous system disorders (2) Ebola virus disease (EVD) (2) Stress urinary incontinence (SUI) (1) Sleep apnoea syndrome (3) Central nervous system tumors (2) Cardiovascular disorders (2) Skin disorders (3) Inflammation (5) Neurofibromatosis (1) Human papillomavirus infections (HPV) (2) Urination disorders (1) Pseudomonas aeruginosa infection (1) Myocardia ischemia (2) Allergic diseases (5) Choroidal neovascularisation (1) Inflammatory pain (2) Chronic fatigue syndrome (1) Blood coagulation disorders (1) Muscular atrophy (1) Pemphigus vulgaris (1) Optic neuritis (1) Immunological disorders (1) Gastrointestinal cancer (1) Pustular psoriasis (1) Psoriatic erythroderma (1) Psoriasis vulgaris (1) Juvenile idiopathic arthritis (JIA) (1) Neuromyelitis optica (NMO) (1) Hirsutism (1) Nasal polyps (1)
Country:
US (64) JP (9) EU (16) GB (2) CN (2) CA (1) CH (3) DE (2) FR (2) NL (1) MX (2) ES (1) AU (1)
Aprv. Year:
1995 (16) 1996 (6) 1997 (7) 1998 (9) 1999 (4) 2000 (2) 2001 (4) 2002 (3) 2003 (3) 2004 (1) 2005 (2) 2006 (5) 2007 (2) 2008 (4) 2009 (5) 2010 (3) 2011 (3) 2012 (5) 2013 (2) 2014 (10) 2015 (4) 2016 (3) 2017 (3)
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