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chemistry (1172) biology (176)
Status:
Approved (275) Withdrawn (17) NDA Filing (29) BLA Filing (2) Phase Ⅲ (150) Phase Ⅱ (473) Phase Ⅰ (396) IND Filing (5)
Clinical Stage:
Pending (182) Active (241) Discontinued (632)
Bio-Type:
Coagulation factor (1) Gene therapy (3) Immunocytokine (3) CAR T cell therapy (1) Vaccine (36) Recombinant enzyme (3) Recombinant polypeptide (1) Recombinant coagulation factor (4) Recombinant cytokines (9) Recombinant hormone (8) Recombinant glycoprotein (1) Bispecific antibody (6) Other recombinant protein (1) Whole antibody (58) ADC (9) Fusion protein (5)
Indication:
Non-alcoholic steatohepatitis (1) Acne (2) Acute bacterial skin and skin structure infections (ABSSSI) (1) Acute coronary syndrome (ACS) (7) Acute cystitis (1) Acute lymphoblastic leukaemia (ALL) (7) Acute myeloid Leukemia (AML) (14) Advanced breast cancer (1) Advanced or metastatic breast cancer (1) Advanced ovarian cancer (1) Advanced renal cell carcinoma (RCC) (2) AIDS-related Kaposi’s sarcoma (1) Alcohol dependence (2) Allergic conjunctivitis (2) Allergic rhinitis (AR) (7) Allergic rhinoconjunctivitis (1) Alzheimer's disease (AD) (45) Amyotrophic lateral sclerosis (ALS) (3) Anaesthetic (2) Anemia (6) Angina pectoris (9) Anxiety (39) Arrhythmia (18) Arthritis (5) Aspergillosis (1) Asthma (50) Atherosclerosis (10) Atopic dermatitis (3) Atopic dermatitis (4) Atrial fibrillation (9) Atrial flutter (3) Attention deficit hyperactivity disorder (ADHD) (1) Basal cell carcinoma (BCC) (2) BCG-refractory carcinoma in situ of the urinary bladder (1) Benign prostatic hypertrophy (15) Bipolar I disorder (1) Bladder cancer (2) Non-diabetic renal diseases (1) Mercury poisoning (1) lead poisoning (1) Breast cancer (31) Bronchial asthma (2) delayed puberty (1) Cancer chemotherapy (1) Cancer related pain (1) Poisoning (1) Candidiasis (3) Hypothyroidism (1) Cardiovascular risk reduction (1) Precocious puberty in children (1) Cerebral vasospasm (1) Keratitis (1) Chemotherapy-induced nausea and vomiting (3) Chemotherapy-induced peripheral neuropathy (1) Oedema (2) Chronic idiopathic urticaria (CIU) (2) Chronic lymphocytic leukemia (CLL) (4) Chronic myeloid leukemia (CML ) (3) Chronic neuropathic pain (1) Episcleritis (1) Chronic obstructive pulmonary disease (COPD) (15) Chronic pain (2) Fever (2) ischaemic heart disorder (8) Menorrhagia (1) Clostridium difficile-associated diarrhea (CDAD) (1) Congenital heart disease (1) Cognitive disorders (13) Colorectal neoplasms (2) Community-acquired bacterial pneumonia (CABP) (1) Giardia lamblia disease (1) Onchocerciasis (1) Community-acquired pneumonia (CAP) (3) Schistosomiasis (1) Complicated intra-abdominal infection (1) Congestive heart failure (3) Constipation (1) Menopausal symptoms (1) Coronary artery disease (CAD) (5) Crohn's disease (8) Vaginal trichomoniasis (1) Cryptococcus neoformans (2) Bradycardia (1) Headache (1) Delayed graft function (1) Cutaneous fungal infections (1) Avian influenza (1) Cutaneous T cell lymphoma (CTCL) (1) Peripheral vascular disorders (2) Cytoprotective adjuvant (1) Iron-deficiency anemia (1) Anaplastic lymphoma kinase (ALK)-positive NSCLC (1) ROS1-positive non-small cell lung cancer(NSCLC) (1) Deep vein thrombosis (DVT) (3) Adrenocortical insufficiency (2) Dementia (1) Depression (16) Amoebiasis (1) Bronchitis (1) Trichomoniasis (1) Diabetic macular edema (5) Diabetic nephropathy (10) Diabetic neuropathic pain (DNP) (2) Herpes simplex virus (2) Diarrhea (2) Infections of the eye (1) Dry age related macular degeneration (AMD) (2) Dry eye disease (2) Duchenne muscular dystrophy (DMD) (1) Duodenal ulcer (3) Dyslipidemia (2) Dysmenorrhea (2) Dyspepsia (2) Dysuria (1) Eczema (2) Emergency contraception (1) Endometrial cancer (3) Rheumatic disorders (8) Endometriosis (3) Transplant rejection (5) Epilepsy/Seizures (16) Erectile dysfunction (ED) (10) Erosion and ulceration (1) Erosive esophagitis (EE) (2) Eye disorders (1) Urogenital cancer (1) Essential hypertension-重复 (2) Essential thrombocythaemia (ET) (2) Familial chylomicronemia syndrome (FCS) (1) Female sexual dysfunction (4) Fibromyalgia (FM) (5) Follicular lymphoma (1) Gastric cancer (10) Gastric ulcer (5) Gastroesophageal reflux disease (GERD) (6) Gastrointestinal stromal tumors (GISTs) (2) Gaucher's disease (GD) (1) Generalised anxiety disorder (GAD) (8) Generalized tonic-clonic status epilepticus (GTCSE) (1) Germline BRCA mutated advanced ovarian cancer (1) Digital ulcers (1) Pancreatitis (1) Glaucoma (3) Glioblastoma multiforme (2) Gonorrhea (3) Gram-positive and Gram-negative bacterial infections (4) Wet age-related macular degeneration (2) Growth hormone deficit (2) Cytomegalovirus infections (5) HBV infection (9) HCV infection (22) Heart failure (25) Hepatocellular carcinoma (HCC) (9) Pediatric plaque psoriasis (1) HIV infection (34) Hormone refractory prostate cancer (1) HSV infection (1) Huntington's disease (3) Hypercalcemia (4) Hypercholesterolemia (14) Hyperlipidemia (19) Hyperparathyroidism (1) Hypertension (44) Hypertriglyceridemia (2) Hyperuricemia (1) Hypogonadotropic hypogonadism (1) Hyponatremia (2) Idiopathic pulmonary fibrosis (IPF) (2) Idiopathic thrombocytopenic purpura (ITP) (1) Inflammatory bowel disease (6) Influenza virus infection (5) Insomnia (14) Invasive aspergillosis (1) Irritable bowel syndrome (IBS) (7) Rabies (1) Juvenile rheumatoid arthritis (JRA) (3) Stevens-Johnson syndrome (1) Leiomyoma (3) Leukemia (8) Pseudomonal infection (1) Lung cancer (8) Lymphoma (7) Macular degeneration (1) Major depressive disorder (MDD) (28) Malignancies (10) Graves ophthalmopathy (1) Malignant brain tumor (1) Mania (1) Mantle cell lymphoma (MCL) (2) Medulloblastoma (1) Melanoma (10) Polymyositis (1) Metastatic breast cancer (3) Metastatic prostate carcinoma (1) Metastatic colorectal cancer (CRC) (2) Metastatic gastric carcinoma (1) Migraine (7) Moderate-to-severe acute pain (1) Mood disorder (1) Multiple myeloma (MM) (5) Multiple sclerosis (MS) (11) Myelodysplastic syndrome (MDS) (4) Myelofibrosis (1) Myeloid leukemia (2) Myocardial infarction (MI) (15) Narcolepsy (1) Nausea and vomiting (4) Systemic amyloidosis (1) Neuropathic pain (10) Erythropoietic protoporphyria (1) Non small cell lung cancer (NSCLC) (28) Non-alcoholic fatty liver disease (NAFLD) (1) Non-Hodgkin B-cell lymphomas (2) Non-Hodgkin’s lymphoma (NHL) (7) Non-ST elevation acute coronary syndrome (NSTE-ACS) (1) Obesity (17) Ocular hypertension (4) Open-angle glaucoma (2) Osteoarthritis (OA) (20) Osteoporosis (5) Nephritis (1) Ovarian cancer (18) Overactive bladder (OAB) (13) Paget's disease (2) Pancreatic cancer (13) Neuroprotection (1) Parkinson's disease (PD) (22) Partial seizures (4) Pelvic inflammatory disease (1) Peptic ulcer (15) Percutaneous coronary intervention (PCI) (2) Perennial allergic rhinitis (1) Peripheral arterial disease (PAD) (5) Peripheral T cell lymphoma (PTCL) (1) Pneumonia (4) Postherpetic neuralgia (PHN) (3) Postmenopausal osteoporosis (8) Postoperative pain (4) Viral infections (2) Post-polycythemia vera (1) Prader-Willi syndrome (1) Premature ejaculation (1) Premature LH surges (1) Thrombosis (1) Kidney disorders (1) Primary hypertension (2) Diphtheria (5) Haemophilus infection (3) Pertussis (5) Prostate cancer (14) Poliomyelitis (2) Tetanus (5) Psoriasis (10) Psoriatic arthritis (4) Pulmonary arterial hypertension (4) Pulmonary embolism (2) Rejection of organ transplantation (2) Renal cell carcinoma (5) Respiratory tract infection (3) Restless legs syndrome (3) Rheumatoid arthritis (RA) (54) Schizophrenia (39) Seasonal allergic rhinitis (3) Zika virus infection (1) Secondary hyperparathyroidism (HPT) (1) Sedation (3) Sensitive anaerobic bacteria infections (1) Sinusitis-重复 (1) Sjoegren's syndrome (1) Skin infectious (1) Sleep disorder (6) Small cell lung cancer (SCLC) (4) Smoking cessation (4) Male infertility (1) Soft tissue infections (1) Soft tissue sarcoma (1) Solid tumours (107) Back pain (1) Stroke and systemic embolism (1) Systemic lupus erythematosus (6) Peanut hypersensitivity (1) Thrombocytopenia (3) Topical bacterial infection (1) Heart arrest (1) Tourette's syndrome (1) Transthyretin familial amyloid polyneuropathy (TTR-FAP) (1) Triple negative breast cancer (1) Tuberculosis (5) Usher syndrome (1) Type 2 diabetes (56) Ulcerative colitis (14) Urinary frequency (2) Urinary incontinence (12) Urinary tract infections (5) Urinary urgency (2) Urticaria (3) Uterine fibroids (1) Uveitis (2) Rhabdomyosarcoma (1) Venous thromboembolism (VTE) (4) Zollinger-Ellison syndrome (1) Reperfusion injury (1) Head and neck cancer (7) Nasopharyngeal cancer (1) Influenza A virus infections (2) Lupus vulgaris (1) Fabry disease (1) Hodgkin lymphoma (3) Colorectal cancer (18) Cryopyrin-Associated Periodic Syndromes (CAPS) (1) Prophylaxis of organ rejection (2) Rejection of renal transplantation (2) Rejection of liver transplantation (2) Rejection of lung transplantation (1) Diabetic complications (1) Myocardial reperfusion injury (1) Rejection of pancreatic transplantation (1) Picornavirus infections (1) Ventricular arrhythmias (2) Diabetes insipidus (1) Ankylosing Spondylitis (AS) (5) Primary dysmenorrhea (PD) (2) Familial adenomatous polyposis (FAP) (2) Life- or limb-threatening infections caused by susceptible strains (2) Acute pain (AP) (2) Low back pain (1) Shoulder periarthritis (1) Tendonitis (1) Cervico-omo-brachial syndrome (1) Pulmonary arterial hypertension secondary to scleroderma (1) After surgery, post-traumatic and anti-inflammatory (1) Nosocomial infections (1) Tinea corporis (1) Tinea cruris (1) Tinea pedis (1) Fungal infection (6) Candidemia (1) Bronchospasm (1) Nosocomial Pneumonia (NP) (2) Osteoporosis in men (1) Glucocorticoid-induced osteoporosis (1) Surgical infection (1) Meningococcal infection (2) Gestational trophoblastic disease (1) Nonseminomatous testicular cancer (1) Endocarditis (1) Recurrent epithelial keratitis (1) Primary keratoconjunctivitis (1) Wilms Tumor (1) 流产 (1) Systemic bacterial infections (1) Colon cancer (4) Complicated skin and skin structure infections (cSSSI) (2) Cirrhosis (1) Dermatitis (2) Hepatitis (1) Skin pruritus (3) Brain oedema (1) Diabetic foot ulcers (1) Spondyloarthritis (1) Estrogen deficiency (1) Nyctalopia (2) Susceptible bacterial infections (3) Chronic heart failure (1) Familial hypercholesterolemia (2) Neuroblastoma (1) Muckle-Wells Syndrome (MWS) (1) Staphylococcus aureus bloodstream infections (1) Age-related macular degeneration (AMD) (8) Serious infections caused by Fusarium spp. (1) Serious fungal infections caused by scedosporium apiospermum (1) Otorhinolaryngological infection (1) Bacterial conjunctivitis (1) Accelerate gastrointestinal recovery following surgeries (1) Pain (31) Acute pain (1) Stroke (10) Advanced breast cancer in postmenopausal women (2) Estrogen-receptor positive early breast cancer (1) Unstable angina (7) Non-ST segment elevation myocardial infarction (NSTEMI) (1) ST-segment elevation myocardial infarction (STEMI) (2) Transthyretin amyloidosis (1) Metastatic non-small cell lung cancer (1) Uncomplicated skin and skin structure infections (1) Enterococcus faecium infections (1) Methicillin-resistant staphylococcus aureus infections (1) Malignant glioma (1) Prevention of postmenopausal osteoporosis (1) Bone pain (1) Hepatic impairment (1) Symptomatic spontaneous superficial-vein thrombosis of the lower limbs (1) Acute pulmonary thromboembolism (1) Autistic disorder (1) Bipolar disorder (1) Dementia with Lewy bodies (1) Acute gouty arthritis (GA) (1) Anesthesia (4) Urothelial cancer (1) Bacterial Pneumonia (2) Bacterial enteritis (1) Prostatitis (2) Cholecystitis (1) Internal genital infections (1) Otitis Media (2) Systemic inflammatory response syndrome (SIRS) (1) Recurrence suppression after ischemic cerebrovascular disorder (1) Stable angina (1) Old myocardial infarction (1) Recent myocardial infarction (1) Cervical carcinoma (2) Pancreatic neuroendocrine tumors (pNET) (1) Lower respiratory tract disease caused by RSV (1) Macular edema (1) Sarcoma (4) B-cell lymphoma (2) Diabetes (14) Diagnostic agents (3) HER2-positive metastatic breast cancer (1) Familial cold autoinflammatory syndrome (1) Malaria (5) Sickle cell disease (2) Type 1 diabetes (3) Sickle cell vaso-occlusive crisis (1) Hemophilia A (1) Hemophilia B (1) Neutropenia (1) Hairy cell leukemia (2) Renal carcinoma (7) Acute myocardial infarction (AMI) (1) Post-traumatic stress disorder (2) Contraception (1) Hypoactive sexual desire disorder (HSDD) (2) Hypertrophic cardiomyopathy (1) Hematological cancer (1) Plasma uric acid management (1) Disseminated intravascular coagulation (DIC) (1) Spinal cord injury (1) Hereditary angioedema (HAE) (2) Spinal muscular atrophy (4) Eosinophilic esophagitis (EoE) (1) Short bowel syndrom (1) Infertility (1) Autoimmune diseases (2) Down's syndrome (1) Obsessive compulsive disorder (3) Acromegaly (1) Growth failure (2) Turner syndrome (1) Small for gestational age (SGA) (1) Idiopathic short stature (1) Acute heart failure (1) Sepsis (2) Septic shock (2) Mycosis fungoides (1) Gram-positive bacterial infection (5) Preterm labor (1) Cardiomyopathy (1) Gram-negative bacterial infection (3) Alcoholism (3) Chemotherapy-radiotherapy induced mucositis (1) Anorexia nervosa (1) Lower urinary tract symptoms (LUTS) (1) Trachomatis infection (1) Respiratory disorders (1) Trypanosomiasis (1) Leishmaniasis (1) Fibrodysplasia ossificans progressiva (FOP) (2) Staphylococcal infection (2) Congenital adrenal hyperplasia (1) Brain injury (4) Clear cell renal cell cancer (ccRCC) (1) Terminate pregnancy (2) Merkel cell carcinoma (1) Bacterial Vaginosis (BV) (2) Glioma (2) Myasthenia (1) Ewing's Sarcoma (1) Liposarcoma (1) Neuroendocrine tumors (NET) (1) Clostridial infection (3) Plaque psoriasis (3) Allergic asthma (2) Gout (1) Thrombosis (22) Panic disorder (2) HRV infection (1) Diabetic retinopathy (2) Enterovirus infection (1) Alopecia (4) Systemic sclerosis (1) Fractures (1) Respiratory syncytial virus infection (2) Raynaud's phenomenon (1) Mesothelioma (1) Diffuse large B cell lymphoma (1) Gastrointestinal disorders (1) Hypogonadism (1) Insulin resistance (1) Dengue fever (1) Interstitial cystitis (1) Vasomotor symptoms (2) Skin hypertrophic scars (1) Brain cancer (2) Lipodystrophy (1) Corneal disorders (1) Bacterial infection (22) Muscle spasticity (3) Cocaine abuse (2) Pervasive child developmental disorder (1) Aortic valve stenosis (1) Celiac disease (2) Poliovirus infection (1) Cough (5) Post-surgical adhesions (1) Stargardt’s disease (1) Bullous pemphigoid (1) Adrenocortical carcinoma (1) Diabetic neuropathy (2) Liver cancer (4) Thelassemia (1) Discoid lupus erythematosus (1) Dermatomyositis (2) Polycystic kidney disease (PKD) (1) Postoperative inflammation (1) Immunodeficiency disorders (1) Renal failure (1) Psychiatric disorders (4) Coronary restenosis (3) Thromboembolism (2) Infectious disease (3) Neurological disease (2) hematological malignancies (1) Central nervous system disorders (2) Ebola virus disease (EVD) (1) Stress urinary incontinence (SUI) (2) Sleep apnoea syndrome (2) Central nervous system tumors (1) Ventricular tachycardia (1) Rhinosinusitis (1) Cardiovascular disorders (2) Skin disorders (3) Inflammation (4) Urination disorders (1) Pseudomonas aeruginosa infection (1) Sialorrhoea (1) Myocardia ischemia (3) Bipolar depression (1) Allergic diseases (2) Choroidal neovascularisation (1) Cachexia (1) Inflammatory pain (3) Chronic fatigue syndrome (1) Muscular atrophy (1) Pemphigus vulgaris (1) Optic neuritis (1) Immunological disorders (1) Muscular dystrophy (1) Juvenile idiopathic arthritis (JIA) (2) Neuromyelitis optica (NMO) (1) Hemophilia (3) Hirsutism (1) Cerebral haemorrhage (1)
Country:
US (76) JP (11) EU (22) GB (4) CN (2) CA (1) CH (3) FR (2) NL (3) IT (1) ES (1) NZ (1)
Aprv. Year:
1995 (21) 1996 (8) 1997 (11) 1998 (11) 1999 (5) 2000 (4) 2001 (6) 2002 (5) 2003 (5) 2004 (2) 2005 (1) 2006 (5) 2007 (3) 2008 (3) 2009 (7) 2010 (4) 2011 (5) 2012 (8) 2013 (2) 2014 (2) 2015 (3) 2016 (1) 2017 (5)
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